Here is My ranking of Desktop Twitter clients:
1. Peoplebrowsr - The best tool out there for monitoring the latest
news. iPhone app, maybe. http://kb.clipotech.com/pbrowsr
2. Mixero - Not so good for many columns, but really great for
filtering and organizing. iPhone app soon. http://kb.clipotech.com/mixero
3. HootSuite - Excellent Twitter client for the user with a lot of
columns. You can even have them organized in tabs! http://kb.clipotech.com/hootsuite
4. Seesmic Desktop - Gets better and better, but still many cool
features from the old Twhirl are missing. iPhone app soon. http://kb.clipotech.com/seesmic
5. TweetDeck - Popular but I think it's a bit clumsy and hard to
organize and filter in it. Ok for monitoring keywords. iPhone app
available. http://kb.clipotech.com/tweetdeck
6. Destroytwitter - Good looking client, but not with so many
features. http://kb.clipotech.com/destroytwitter
That's it! :)
Follow me on Twitter: http://twitter.com/svartling
Buzz it!